Ipo iṣe ti Thiamethoxam jẹ aṣeyọri nipa didamu eto aifọkanbalẹ ti kokoro ti a fojusi nigbati kokoro yala jẹ tabi fa majele sinu ara rẹ.Kokoro ti o han gbangba npadanu iṣakoso ti ara wọn ati jiya awọn aami aiṣan bii gbigbọn ati gbigbọn, paralysis, ati iku nikẹhin.Thiamethoxam ni imunadoko iṣakoso mimu ati jijẹ kokoro bii aphids, whitefly, thrips, ricehoppers, ricebugs, mealybugs, funfun grubs, poteto beetles, flea beetles, wireworms, ilẹ beetles, ewe miners, ati diẹ ninu awọn eya lepidopterous.